Steatitis may occur without skin destruction in some cases.Toxic shock syndrome may ensue as a result of tissue destruction and haematogenous spread of endotoxins and inflammatory mediators.Toxin-induced thrombosis and vasoconstriction in infected tissue, and surrounding skin and muscle results in decreased tissue viability and increased spread of infection.Bacteria produce endotoxins and proteases that cause local tissue damage, creating a nidus for bacterial proliferation.Bacteria gain entry from wound, or haematogenous spread and localise in fascia/muscle.The following is a brief description of the progression of infection to overt disease 1-3 : Where no wound is found, it is assumed bacteria gain entry to tissues from haematogenous routes.Surgical sites may be recent, or may be many years old e.g. ![]() Case reports in veterinary literature have cited injection sites for subcutaneous fluid administration, and small wounds as potential points of entry for causative organisms.
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